Organogenesis is a conventional research area in developmental biology. Recent research progresses on stem cell, epigenetics, no-coding RNA and other new properties of multicellular organisms have transformed the organogenesis research as a frontier of life science. The collection of six research papers in this issue aims to cover timely developments in the research area of organogenesis from basic mechanism analysis to applied medical potential.
In the first article, Dr Wu's group reported that knockdown of the members of the cadherin cell adhesion superfamily proteins, protocadherin (Pcdh) clusters, resulted in dendritic simplification and spine defects in vivo and in cultured primary hippocampal neurons in vitro. Furthermore, the knockdown of the …